WILMINGTON, DE & MUNICH, Germany — NRx Pharmaceuticals Inc. (Nasdaq: NRXP) and neurocare Group AG have announced a partnership to build a nationwide network of clinics offering integrated neuroplastic care for depression, post-traumatic stress disorder, and other serious mental health conditions, positioning the effort as a response to what both companies describe as a fragmented and ineffective treatment landscape.
The collaboration combines neurocare’s neuromodulation technology platform and clinic infrastructure with NRx’s neuroplastic drug development and clinical operations through its HOPE Therapeutics brand. Central to the strategy is immediate access to more than 400 installed Apollo transcranial magnetic stimulation machines across the United States, allowing the partners to scale quickly without constructing an entirely new physical footprint.
Executives said pilot programs, including one conducted with a state first-responder agency, demonstrated strong outcomes by combining TMS with ketamine and other neuroplastic medications, hyperbaric oxygen therapy, and structured psychotherapy. The approach produced high remission rates among first responders suffering from PTSD and depression, populations that have historically shown resistance to conventional treatments.
Recent peer-reviewed research cited by the companies reported response rates of up to 87 percent and remission rates of 72 percent in patients with treatment-resistant depression when TMS was integrated with neuroplastic drug therapy. While the companies emphasized that the data remain preliminary and subject to further validation, they said the results justify broader clinical deployment and expanded regulatory engagement.
Beyond depression and PTSD, the partners are exploring joint clinical trials and regulatory pathways targeting bipolar depression, autism spectrum disorder, and traumatic brain injury, including studies involving NRx’s investigational drug NRX-101.
The partnership reflects an attempt to industrialize mental health care delivery in a manner similar to how complex specialty care has been standardized in other fields. neurocare was founded by former executives of Fresenius Medical Care, a company credited with creating scalable, protocol-driven models for dialysis treatment. neurocare has spent more than a decade developing an integrated platform that includes neuromodulation technologies, clinician training programs, and proprietary software designed to standardize intake, treatment selection, and patient monitoring.
NRx brings parallel experience in neuroplastic drug development and clinic-based care through HOPE Therapeutics, which already contracts with government programs including the VA Community Care Network and the Department of Defense’s TRICARE system. Both companies said they see accountable, integrated care models as essential to securing payer participation in a market dominated by standalone clinics offering isolated therapies.
The alliance will initially rely on neurocare and HOPE Therapeutics clinics, currently numbering about 20 in the United States, while inviting participation from independent providers operating Apollo TMS systems. The stated goal is to make integrated neuroplastic treatment available within driving distance of most U.S. households by the end of 2026.
Executives framed the initiative as both a clinical and commercial inflection point. Serious central nervous system disorders affect more than 50 million people in the United States and roughly 500 million worldwide, representing one of health care’s largest unmet needs. By offering a single point of accountable care to patients and insurers, the companies aim to reduce treatment fragmentation while creating a scalable business model in a sector under increasing scrutiny for outcomes and cost control.
Leaders from both organizations are scheduled to present the strategy to investors and industry stakeholders at the upcoming JP Morgan Healthcare Conference in San Francisco, signaling the partnership’s ambition to become a national platform rather than a limited clinical collaboration.
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