Xu, R. et al. Wildfires, global climate change, and human health. N. Engl. J. Med. 383, 2173–2181 (2020).
Xu, R. et al. Global, regional, and national mortality burden attributable to air pollution from landscape fires: a health impact assessment study. Lancet 404, 2447–2459 (2024).
Brokamp, C., Strawn, J. R., Beck, A. F. & Ryan, P. Pediatric psychiatric emergency department utilization and fine particulate matter: a case-crossover study. Environ. Health Perspect. 127, 097006 (2019).
Kieling, C. et al. Child and adolescent mental health worldwide: evidence for action. Lancet 378, 1515–1525 (2011).
Arnold, L. E., Hodgkins, P., Kahle, J., Madhoo, M. & Kewley, G. Long-term outcomes of ADHD: academic achievement and performance. J. Atten. Disord. 24, 73–85 (2020).
Zhang, Y. et al. Health impacts of wildfire smoke on children and adolescents: a systematic review and meta-analysis. Curr. Environ. Health Rep. 11, 46–60 (2024).
Zhang, Y. et al. Short-term exposure to wildfire-specific pm2.5 and diabetes hospitalization: a study in multiple countries and territories. Diabetes Care 47, 1664–1672 (2024).
Muhsin, H. A., Steingrimsson, S., Oudin, A., Åström, D. O. & Carlsen, H. K. Air pollution and increased number of psychiatric emergency room visits: a case-crossover study for identifying susceptible groups. Environ. Res. 204, 112001 (2022).
Bryant, R. A. et al. Longitudinal study of changing psychological outcomes following the Victorian Black Saturday bushfires. Aus. N. Z. J. Psychiatry 52, 542–551 (2018).
Brown, M. R. et al. After the Fort McMurray wildfire there are significant increases in mental health symptoms in grade 7–12 students compared to controls. BMC Psychiatry 19, 18 (2019).
McFarlane, A. C. & Van Hooff, M. Impact of childhood exposure to a natural disaster on adult mental health: 20-year longitudinal follow-up study. Br. J. Psychiatry 195, 142–148 (2009).
Air Quality System (AQS) (US EPA, 2025); https://www.epa.gov/aqs
Xie, Y. et al. Daily estimation of ground-level PM2.5 concentrations over Beijing using 3 km resolution MODIS AOD. Environ. Sci. Technol. 49, 12280–12288 (2015).
Grell, G. A. et al. Fully coupled ‘online’ chemistry within the WRF model. Atmos. Environ. 39, 6957–6975 (2005).
Reid, J. S., Koppmann, R., Eck, T. F. & Eleuterio, D. P. A review of biomass burning emissions part II: intensive physical properties of biomass burning particles. Atmos. Chem. Phys. 5, 799–825 (2005).
Xu, R. et al. Global population exposure to landscape fire air pollution from 2000 to 2019. Nature 621, 521–529 (2023).
Hajat, S., Armstrong, B. G., Gouveia, N. & Wilkinson, P. Mortality displacement of heat-related deaths: a comparison of Delhi, Sao Paulo, and London. Epidemiology 16, 613–620 (2005).
Bhui, K. et al. Air quality and mental health: evidence, challenges and future directions. BJPsych Open 9, e120 (2023).
Syed, A. & Basu, R. The effect of wildfire smoke on children’s health: a systematic review. Paediatr. Perinat. Epidemiol. 39, 110–119 (2025).
Eisenman, D. P. & Galway, L. P. The mental health and well-being effects of wildfire smoke: a scoping review. BMC Public Health 22, 2274 (2022).
Newbury, J. B. et al. Association of air pollution exposure with psychotic experiences during adolescence. JAMA Psychiatry 76, 614–623 (2019).
Szyszkowicz, M. et al. Air pollution and emergency department visits for mental disorders among youth. Int. J. Environ. Res. Public Health 17, 4190 (2020).
Roberts, S. et al. Exploration of NO2 and PM2.5 air pollution and mental health problems using high-resolution data in London-based children from a UK longitudinal cohort study. Psychiatry Res. 272, 8–17 (2019).
Ahmed, S. M. et al. Maternal and childhood ambient air pollution exposure and mental health symptoms and psychomotor development in children: an Australian population-based longitudinal study. Environ. Int. 158, 107003 (2022).
Oudin, A., Bråbäck, L., Åström, D. O., Strömgren, M. & Forsberg, B. Association between neighbourhood air pollution concentrations and dispensed medication for psychiatric disorders in a large longitudinal cohort of Swedish children and adolescents. BMJ Open 6, e010004 (2016).
Song, R. et al. Short-term exposure to air pollution is an emerging but neglected risk factor for schizophrenia: a systematic review and meta-analysis. Sci. Total Environ. 854, 158823 (2023).
Buoli, M. et al. Is there a link between air pollution and mental disorders? Environ. Int. 118, 154–168 (2018).
Buoli, M. et al. The role of clock genes in the etiology of major depressive disorder: special section on ‘Translational and Neuroscience Studies in Affective Disorders’. Section editor, Maria Nobile MD, PhD. This section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. J. Affect. Disord. 234, 351–357 (2018).
Plotsky, P. M., Owens, M. J. & Nemeroff, C. B. Psychoneuroendocrinology of depression: hypothalamic–pituitary–adrenal axis. Psychiatr. Clini. North Am. 21, 293–307 (1998).
Calderón-Garcidueñas, L. et al. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood–brain barrier, ultrafine particulate deposition, and accumulation of amyloid β-42 and α-synuclein in children and young adults. Toxicol. Pathol. 36, 289–310 (2008).
Levesque, S. et al. Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. Environ. Health Perspect. 119, 1149–1155 (2011).
Cao, B., Chen, Y. & McIntyre, R. S. Comprehensive review of the current literature on impact of ambient air pollution and sleep quality. Sleep Med. 79, 211–219 (2021).
Liu, L. et al. The effect of PM2.5 exposure and risk perception on the mental stress of Nanjing citizens in China. Chemosphere 254, 126797 (2020).
Tolppanen, A.-M. et al. Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood. PLoS ONE 7, e41575 (2012).
Pignon, B. et al. PM2.5 and PM10 air pollution peaks are associated with emergency department visits for psychotic and mood disorders. Environ. Sci. Pollut. Res. 29, 88577–88586 (2022).
Bai, L. et al. Ambient air pollution and hospitalizations for schizophrenia in China. JAMA Netw. Open 7, e2436915 (2024).
Attademo, L., Bernardini, F., Garinella, R. & Compton, M. T. Environmental pollution and risk of psychotic disorders: a review of the science to date. Schizophr. Res. 181, 55–59 (2017).
Wichstrøm, L. et al. Prevalence of psychiatric disorders in preschoolers. J. Child Psychol. Psychiatry 53, 695–705 (2012).
Air Pollution and Child Health: Prescribing Clean Air: Summary (WHO, 2018).
Bratman, G. N. et al. Nature and mental health: an ecosystem service perspective. Sci. Adv. 5, eaax0903 (2019).
Evans, G. W. & Kim, P. Childhood poverty, chronic stress, self-regulation, and coping. Child Dev. Perspect. 7, 43–48 (2013).
Clifford, A., Lang, L., Chen, R., Anstey, K. J. & Seaton, A. Exposure to air pollution and cognitive functioning across the life course—a systematic literature review. Environ. Res. 147, 383–398 (2016).
Frances, S. 6 facts about mental health in Brazil. The Borgen Project https://borgenproject.org/mental-health-in-brazil/ (2020).
Paula, C. S., Duarte, C. S. & Bordin, I. A. Prevalence of mental health problems in children and adolescents from the outskirts of Sao Paulo City: treatment needs and service capacity evaluation. Braz. J. Psychiatry 29, 11–17 (2006).
Wu, Y. et al. Wildfire-related PM2.5 and health economic loss of mortality in Brazil. Environ. Int. 174, 107906 (2023).
Paula, C. S., Lauridsen-Ribeiro, E., Wissow, L., Bordin, I. A. S. & Evans-Lacko, S. How to improve the mental health care of children and adolescents in Brazil: actions needed in the public sector. Braz. J. Psychiatry 34, 334–341 (2012).
Jacob, D. J. & Winner, D. A. Effect of climate change on air quality. Atmos. Environ. 43, 51–63 (2009).
Van der Werf, G. R. et al. Global fire emissions and the contribution of deforestation, savanna, forest, agricultural, and peat fires (1997–2009). Atmos. Chem. Phys. 10, 11707–11735 (2010).
Smith, G. S. et al. Air pollution and pulmonary tuberculosis: a nested case–control study among members of a northern California health plan. Environ. Health Perspect. 124, 761–768 (2016).
Clayton, S. Climate anxiety: psychological responses to climate change. J. Anxiety Disord. 74, 102263 (2020).
Lam, M. K. How good is New South Wales admitted patient data collection in recording births? Health Inf. Manage. 40, 12–19 (2011).
Nakamura-Pereira, M., Mendes-Silva, W., Dias, M. A., Reichenheim, M. E. & Lobato, G. The Hospital Information System of the Brazilian Unified National Health System: a performance evaluation for auditing maternal near miss. Cad. Saude Publica 29, 1333–1345 (2013).
Amuah, J. E. et al. Development and validation of a hospital frailty risk measure using Canadian clinical administrative data. CMAJ 195, E437–E448 (2023).
GPW: Gridded Population of the World (NASA, accessed 11 November 2023); https://www.earthdata.nasa.gov/data/projects/gpw
Data from Gridded Global Datasets for Gross Domestic Product and Human Development Index over 1990–2015 (Dryad, accessed 11 November 2023); https://doi.org/10.5061/dryad.dk1j0
CIESIN Global Gridded Deprivation Index (GRDI), Version 1 Version 1.00 (NASA, accessed 11 November 2023); https://www.earthdata.nasa.gov/data/catalog/sedac-ciesin-sedac-pmp-grdi-2010-2020-1.00
Ouyang, Z. et al. Improving estimates of built-up area from night time light across globally distributed cities through hierarchical modeling. Sci. Total Environ. 647, 1266–1280 (2019).
ERA5 (ECMWF, accessed 3 January 2025); https://www.ecmwf.int/en/forecasts/datasets/reanalysis-datasets/era5
Tarek, M., Brissette, F. P. & Arsenault, R. Evaluation of the ERA5 reanalysis as a potential reference dataset for hydrological modelling over North America. Hydrol. Earth Syst. Sci. 24, 2527–2544 (2020).
Urraca, R. et al. Evaluation of global horizontal irradiance estimates from ERA5 and COSMO-REA6 reanalyses using ground and satellite-based data. Sol. Energy 164, 339–354 (2018).
Zhang, Y. et al. Respiratory risks from wildfire-specific PM2.5 across multiple countries and territories. Nat. Sustain. 8, 474–484 (2025).
Gasparrini, A., Armstrong, B. & Kenward, M. G. Multivariate meta-analysis for non-linear and other multi-parameter associations. Stat. Med. 31, 3821–3839 (2012).