Wesselhoeft, R., Sørensen, M. J., Heiervang, E. R. & Bilenberg, N. Subthreshold depression in children and adolescents – a systematic review. J. Affect Disord. 151, 7–22 (2013).

Article 
PubMed 

Google Scholar
 

Balázs, J. et al. Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk. J. Child Psychol. Psychiatry 54, 670–677 (2013).

Article 
PubMed 

Google Scholar
 

Klein, D. N., Shankman, S. A., Lewinsohn, P. M. & Seeley, J. R. Subthreshold depressive disorder in adolescents: predictors of escalation to full-syndrome depressive disorders. J. Am. Acad. Child Adolesc. Psychiatry 48, 703–710 (2009).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Horwath, E., Johnson, J., Klerman, G. L. & Weissman, M. M. Depressive symptoms as relative and attributable risk factors for first-onset major depression. Arch. Gen. Psychiatry 49, 817–823 (1992).

Article 
CAS 
PubMed 

Google Scholar
 

Judd, L. L., Schettler, P. J. & Akiskal, H. S. The prevalence, clinical relevance, and public health significance of subthreshold depressions. Psychiatr. Clin. North Am. 25, 685–698 (2002).

Article 
PubMed 

Google Scholar
 

Crockett, M. A., Martínez, V. & Jiménez-Molina, Á Subthreshold depression in adolescence: gender differences in prevalence, clinical features, and associated factors. J. Affect Disord. 272, 269–276 (2020).

Article 
PubMed 

Google Scholar
 

Liu, L. & Zhu, G. Gut-brain axis and mood disorder. Front. Psychiatry 9, 223 (2018).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Yang, J. et al. Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders. Sci. Adv. 6, eaba8555 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Desbonnet, L. et al. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 170, 1179–1188 (2010).

Article 
CAS 
PubMed 

Google Scholar
 

Lyte, M. Microbial endocrinology in the microbiome-gut-brain axis: how bacterial production and utilization of neurochemicals influence behavior. PLoS Pathog. 9, e1003726 (2013).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Radjabzadeh, D. et al. Gut microbiome-wide association study of depressive symptoms. Nat. Commun. 13, 7128 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Jiang, H. et al. Altered fecal microbiome composition in patients with major depressive disorder. Brain Behav. Immun. 48, 186–194 (2015).

Article 
PubMed 

Google Scholar
 

Ling, Z. et al. Changes in fecal microbiome composition and the cytokine expression profile in school-aged children with depression: a case-control study. Front Immunol. 13, 964910 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

McGuinness, A. J. et al. A systematic review of gut microbiome composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia. Mol. Psychiatry 27, 1920–1935 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Zhou, Y. et al. Fecal microbiome changes in patients with postpartum depressive disorder. Front. Cell Infect. Microbiol. 10, 567268 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Wallace, C. J. K. & Milev, R. The effects of probiotics on depressive symptoms in humans: a systematic review. Ann. Gen. Psychiatry 16, 14 (2017).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Nikolova, V. L. et al. Perturbations in gut microbiome composition in psychiatric disorders: a review and meta-analysis. JAMA Psychiatry 78, 1343–1354 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Kelly, J. R. et al. Transferring the blues: depression-associated gut microbiome induces neurobehavioral changes in the rat. J. Psychiatr. Res. 82, 109–118 (2016).

Article 
PubMed 

Google Scholar
 

Zhang, J. P. Structural characteristics of intestinal flora in subthreshold depressed people and the influence of TCM constitution on their intestinal flora structure. Med. Health Technol. https://doi.org/10.26973/d.cnki.gbjzu.2020.000108 (2021).

Calarge, C. A., Devaraj, S. & Shulman, R. J. Gut permeability and depressive symptom severity in unmedicated adolescents. J. Affect Disord. 246, 586–594 (2019).

Article 
PubMed 

Google Scholar
 

Wang, R. et al. Exercise effect on the gut microbiome in young adolescents with subthreshold depression: a randomized psychoeducation-controlled Trial. Psychiatry Res. 319, 115005 (2023).

Article 
CAS 
PubMed 

Google Scholar
 

Li, M. F. et al. Cognitive and brain mechanisms of subthreshold depression. Psychol. Month. https://doi.org/10.19738/j.cnki.psy.2023.05.071 (2023).

Gao, Z. Y. et al. Progress on subthreshold depression in the elderly with mild cognitive impairment. Chin. J. Psychiatry 54, 296–299 (2021).


Google Scholar
 

Yao, Q. K. et al. Clinical value of serum HDAC3 and BDNF levels in the diagnosis of cognitive function in adolescents with subthreshold depression old depression. Chin. J. Difficult Complicate. Cases 22, 5 (2023).


Google Scholar
 

Wang, Z. et al. Gut microbiome modulates the inflammatory response and cognitive impairment induced by sleep deprivation. Mol. Psychiatry 26, 6277–6292 (2021).

Article 
CAS 
PubMed 

Google Scholar
 

Cooke, M. B., Catchlove, S. & Tooley, K. L. Examining the influence of the human gut microbiome on cognition and stress: a systematic review of the literature. Nutrients 14, 4623 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Tooley, K. L. Effects of the human gut microbiome on cognitive performance. Brain structure and function: a narrative review. Nutrients 12, 3009 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Mailing, L. J. et al. Exercise and the gut microbiome: a review of the evidence, potential mechanisms, and implications for human health. Exerc Sport Sci. Rev. 47, 75–85 (2019).

Article 
PubMed 

Google Scholar
 

Codella, R., Luzi, L. & Terruzzi, I. Exercise has the guts: How physical activity may positively modulate gut microbiome in chronic and immune-based diseases. Dig. Liver Dis. 50, 331–341 (2018).

Article 
PubMed 

Google Scholar
 

Patel, V. et al. Mental health of young people: a global public-health challenge. Lancet Lond. Engl. 369, 1302–1313 (2007).

Article 

Google Scholar
 

Regeer, E. J. et al. A prospective study of the transition rates of subthreshold (hypo)mania and depression in the general population. Psychol. Med. 36, 619–627 (2006).

Article 
CAS 
PubMed 

Google Scholar
 

Lin, K. et al. Aerobic exercise impacts the anterior cingulate cortex in adolescents with subthreshold mood syndromes: a randomized controlled trial study. Transl. Psychiatry 10, 155 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Correll, C. U. et al. Differentiation in the preonset phases of schizophrenia and mood disorders: evidence in support of a bipolar mania prodrome. Schizophr. Bull. 33, 703–714 (2007).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Tsai, F. J. et al. Patient health questionnaire for school-based depression screening among Chinese adolescents. Pediatrics 133, e402–e409 (2014).

Article 
PubMed 

Google Scholar
 

Wang, W. et al. Reliability and validity of the Chinese version of the Patient Health Questionnaire (PHQ-9) in the general population. Gen. Hosp. Psychiatry 36, 539–544 (2014).

Article 
PubMed 

Google Scholar
 

Liang, L. et al. The mediating roles of emotional regulation on negative emotion and Internet addiction among Chinese adolescents from a development perspective. Front. Psychiatry 12, 608317 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Qin, J. et al. A metagenome-wide association study of gut microbiome in type 2 diabetes. Nature 490, 55–60 (2012).

Article 
CAS 
PubMed 

Google Scholar
 

Luo, R. et al. SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. GigaScience 1, 18 (2012).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Kent, W. J. BLAT, the BLAST-like alignment tool. Genome Res. 12, 656–664 (2002).

CAS 
PubMed 
PubMed Central 

Google Scholar
 

Liu, R. et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat. Med. 23, 859–868 (2017).

Article 
CAS 
PubMed 

Google Scholar
 

Le Chatelier, E. et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541–546 (2013).

Article 
PubMed 

Google Scholar
 

Karlsson, F. H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498, 99–103 (2013).

Article 
CAS 
PubMed 

Google Scholar
 

Karlsson, F. H. et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat. Commun. 3, 1245 (2012).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Qin, J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59–65 (2010).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Powell, S. et al. EggNOG v3. 0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges. Nucleic Acids Res. 40, D284–D289 (2012).

Article 
CAS 
PubMed 

Google Scholar
 

Kibria, H. B. et al. An ensemble approach for the prediction of diabetes mellitus using a soft voting classifier with an explainable AI. Sensors 22, 7268 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Ijaz, M. F., Attique, M. & Son, Y. Data-driven cervical cancer prediction model with outlier detection and over-sampling methods. Sensors 20, 2809 (2020).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Chen, J. J. et al. Age-specific differential changes on gut microbiome composition in patients with major depressive disorder. Aging 12, 2764–2776 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Bzdok, D. & Meyer-Lindenberg, A. Machine learning for precision psychiatry: opportunities and challenges. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 3, 223–230 (2018).

PubMed 

Google Scholar
 

Rong, H. et al. Similarly in depression, nuances of gut microbiota: evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients. J. Psychiatr. Res. 113, 90–99 (2019).

Article 
PubMed 

Google Scholar
 

Thomas, A. M. et al. Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation. Nat. Med. 25, 667–678 (2019).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Lai, W. T. et al. Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiome in major depressive disorder patients. Psychol. Med. 51, 90–101 (2021).

Article 
PubMed 

Google Scholar
 

Körner, M. & Gebbers, J. O. Clinical significance of human intestinal spirochetosis, a morphologic approach. Infection 31, 341–349 (2003).

Article 
PubMed 

Google Scholar
 

Tsinganou, E. & Gebbers, J. O. Human intestinal spirochetosis-a review. Ger Med. Sci. 8, Doc01 (2010).

PubMed 
PubMed Central 

Google Scholar
 

Fallon, B. A. et al. Lyme borreliosis and associations with mental disorders and suicidal behavior: a nationwide Danish cohort study. Am. J. Psychiatry 178, 921–931 (2021).

Article 
PubMed 

Google Scholar
 

Garakani, A. & Mitton, A. G. New-onset panic, depression with suicidal thoughts, and somatic symptoms in a patient with a history of Lyme disease. Case Rep. Psychiatry 2015, 457947 (2015).

PubMed 
PubMed Central 

Google Scholar
 

Fallon, B. A. et al. Psychiatric manifestations of Lyme borreliosis. J. Clin. Psychiatry 54, 263–268 (1993).

CAS 
PubMed 

Google Scholar
 

Yang, Q. et al. Chronic minocycline treatment exerts antidepressant effect, inhibits neuroinflammation, and modulates gut microbiome in mice. Psychopharmacology 237, 3201–3213 (2020).

Article 
CAS 
PubMed 

Google Scholar
 

Vindegaard, N. et al. Gut microbial changes of patients with psychotic and affective disorders: a systematic review. Schizophr. Res. 234, 1–10 (2021).

Article 
PubMed 

Google Scholar
 

Fallon, B. A. & Nields, J. A. Lyme disease: a neuropsychiatric illness. Am. J. Psychiatry 151, 1571–1583 (1994).

Article 
CAS 
PubMed 

Google Scholar
 

Keilp, J. G. et al. Neurocognition in post-treatment Lyme disease and major depressive disorder. Arch. Clin. Neuropsychol. 34, 466–480 (2019).

Article 
PubMed 

Google Scholar
 

Wang, S. et al. Antibiotic-induced microbiome depletion is associated with resilience in mice after chronic social defeat stress. J. Affect Disord. 260, 448–457 (2020).

Article 
CAS 
PubMed 

Google Scholar
 

Francis, C. Y., Morris, J. & Whorwell, P. J. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharm. Ther. 11, 395–402 (1997).

Article 
CAS 

Google Scholar
 

Jiang, R. et al. Gut microbiome is involved in the antidepressant effects of adipose-derived mesenchymal stem cells in chronic social defeat stress mouse model. Psychopharmacology 239, 533–549 (2022).

Article 
CAS 
PubMed 

Google Scholar
 

Malan-Müller, S. et al. The gut-microbiome-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiome composition linked to anxiety, trauma, and depression profiles. Gut Microbes 15, 2162306 (2023).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Berube, F. R. et al. Self-reported sleep is associated with central, but not peripheral blood pressure values in healthy children. Sleep 43, A53–A53 (2020).

Article 

Google Scholar
 

Riemann, D. et al. Sleep, insomnia, and depression. Neuropsychopharmacology 45, 74–89 (2020).

Article 
PubMed 

Google Scholar
 

Kenna, J. E. et al. Changes in the gut microbiome and predicted functional metabolic effects in an Australian Parkinson’s disease cohort. Front. Neurosci. 15, 756951 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Shao, M. S. et al. Co-digestion of food waste and hydrothermal liquid digestate: promotion effect of self-generated hydrochars. Environ. Sci. Ecotechnol. 15, 100239 (2023).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Yang, Y. et al. Prebiotics for depression: How does the gut microbiota play a role? Front. Nutr. 10, 1206468 (2023).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Ashaie, S. A., Hurwitz, R. & Cherney, L. R. Depression and subthreshold depression in stroke-related aphasia. Arch. Phys. Med Rehabil. 100, 1294–1299 (2019).

Article 
PubMed 

Google Scholar
 

Dotson, V. M. et al. Longitudinal study of chronic depressive symptoms and regional cerebral blood flow in older men and women. Int. J. Geriatr. Psychiatry 24, 809–819 (2009).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Vonetta, M. D. et al. Depression and cognitive control across the lifespan: a systematic review and meta-analysis. Neuropsychol Rev. 30, 461–476 (2020).

Article 

Google Scholar
 

Sun, Z. et al. Characteristics of cognitive deficit in amnestic mild cognitive impairment with subthreshold depression. J. Geriatr. Psychiatry Neurol. 32, 344–353 (2019).

Article 
PubMed 

Google Scholar
 

Sheppard, L. C. & Teasdale, J. D. How does dysfunctional thinking decrease during recovery from major depression? J. Abnorm Psychol. 113, 64–71 (2004).

Article 
PubMed 

Google Scholar
 

Lin, P. et al. Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder. J. Affect Disord. 207, 300–304 (2017).

Article 
PubMed 

Google Scholar
 

Rock, P. L. et al. Cognitive impairment in depression: a systematic review and meta-analysis. Psychol. Med. 44, 2029–2040 (2014).

Article 
CAS 
PubMed 

Google Scholar
 

Galts, C. P. C. et al. Depression in neurodegenerative diseases: common mechanisms and current treatment options. Neurosci. Biobehav. Rev. 102, 56–84 (2019).

Article 
PubMed 

Google Scholar
 

Loh, J. S. et al. Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. Signal Transduct. Target Ther. 9, 37 (2024).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Cenit, M. C., Sanz, Y. & Codoñer-Franch, P. Influence of gut microbiota on neuropsychiatric disorders. World J. Gastroenterol. 23, 5486–5498 (2017).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Socała, K. et al. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. Pharm. Res. 172, 105840 (2021).

Article 

Google Scholar
 

Kim, S. H. et al. Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex. Psychopharmacology 239, 443–454 (2022).

Article 
CAS 
PubMed 

Google Scholar
 

Chen, H. et al. Gene expression alterations in bipolar disorder postmortem brains. Bipolar Disord. 15, 177–187 (2013).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Volkert, J. et al. Evidence for cognitive subgroups in bipolar disorder and the influence of subclinical depression and sleep disturbances. Eur. Neuropsychopharmacol. J. 25, 192–202 (2015).

Article 
CAS 

Google Scholar
 

Bokma, W. A. et al. Predicting the naturalistic course in anxiety disorders using clinical and biological markers: a machine learning approach. Psychol. Med. 52, 57–67 (2022).

Article 
PubMed 

Google Scholar
 

Caldirola, D. et al. First-onset major depression during the COVID-19 pandemic: a predictive machine learning model. J. Affect Disord. 310, 75–86 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Ziobrowski, H. N. et al. Development and validation of a model to predict posttraumatic stress disorder and major depression after a motor vehicle collision. JAMA Psychiatry 78, 1228–1237 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

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