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The Future Of Depression Treatment



The Future Of Depression Treatment

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Dealing with depression is not easy, and the most common treatments don’t work for everyone. Could biomarkers be the key to finding more treatment options?

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Sources:
http://www.canbind.ca/research/why-and-how-we-study-depression/

publications


https://www.sciencedirect.com/science/article/pii/S0165032717309400?via%3Dihub
https://www.sciencedirect.com/science/article/pii/S0165032717310431
https://www.sciencedirect.com/science/article/pii/S0022395618310069
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512908/
https://www.sciencedirect.com/science/article/pii/S0022395617307185
https://www.ncbi.nlm.nih.gov/gene/1565
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078627/

View 43 Comments

43 Comments

  4. @NotUrGrandmas...AnythingReally on

    A couple months ago my doctor offered a test done via cheek swab that can point to medications that are more likely to work. I can't remember what it was called (the thing is, being depressed for decades, you don't really have much hope that anything will work, so it's hard to even take the initiative to get the test.)

  6. @AdelWolf on

    It is so cool that this has come up! Mentioning CYP2D6 reminded me that there is a company called Genomind that your psych doc can send a sample to that will run genetic tests to find these genetic markers, and send back a report that shows you what genes express in which way, and how that changes how medications effect you. When I had mine done, I learned that I have a duplication in CYP2D6 (and CYP2C19) which makes me an ultra-rapid metabolizer. Knowing that, they could list which medications are metabolized by those enzymes and I can steer clear of them since I would have to take super-high doses to get the same effect as someone without the dupe. Funnily enough, the med I was on at the time (Celexa) was on that list.

  7. @TheDentrassi on

    I signed up to donate a saliva swab to a research group looking into this.
    Since getting the kit my own paranoia/anxiety over how this data could be used has stopped me from returning the sample.
    I'm just a bit concerned that the information could be used to predict who is likely to suffer with mental health problems and used to hike health insurance or more sinister goals.
    It's not that long since the mentally ill were institutionalised in some pretty dire conditions.

  8. @tracy9610 on

    There's another ongoing research study called bsnip (bipolar+schizophrenic network for intermediate phenotypes). I've been participating in this one for about a year now. I have high hopes for this area of research.

  9. @MagiciteHeart on

    I got very confused when you said that this wasn't known or ready, because I literally just did a cheek swab for this exact purpose a couple months ago. I've been struggling to find effective medicine, and when my doctor told me about this he totally made it sound like it was already a thing. Now I've got some questions.

  10. @SimplySnake38 on

    You're telling me if you figure out what the depression is a symptom of you can treat it!?!? Biohackers already did that and me and my new GF is proof of this. depression treated successfully.

  11. @ktjg911 on

    Idk if i have depression or not. Ive been called fat n obese from my friends and family. Having harsh times with my family members and having suicidal thoughts.whenever i cry i beat my chest cause my heart hurts so much n i always wanna say sry to myself n to another if i hav done wrong

  12. @elijahtrent21 on

    If you had to be strapped to a chair everyday and be electrocuted and go to sleep in a Dog cage fed Dog food for 3 months to get rid of your depression would you do it ?

  15. @mouseluva on

    Almost in tears thinking about how different my life could be if I didn't have to treat my mental illness with years of temporary fixes through ineffective and sometimes dangerous trial and error

  22. @susanrobinson910 on

    This is a truly fascinating topic and I sincerely hope that one day, treating depression, as well as other conditions that require medications/therapy, will be as easy as a blood test. As someone who has suffered with crippling depression and anxiety for as long as I can remember, I am hopeful that one day I won't be living with these overwhelming elephants on my back. I wish that for everyone…

  24. @LifeLostSoul on

    I got the generic testing for my antidepressants and ADHD meds and I just wish they had it in the early stages of my prescribing because it took 7 antidepressants for me to get to the one I'm on and one of those landed me in the ER. And the genetic tests said I probably wouldn't react the best with pretty much every single one I've been given. Nice thing was the genetic test was covered by my insurance. I'm also not supposed to take folic acid.

  29. @Lukos0036 on

    We need more cures for mental health problems. Some have experienced improvement with exposure to electromagnetic fields, or direct electrical stimulation. There have to be more permanent non chemical treatments for depression and anxiety.

  33. @ditzkrakendigo8299 on

    I had semi-treatment resistant depression as a teenager, this means that the standard treatment option SSRIs weren't working fully. My med manager had me get tested for one gene, MTHFR, which effects processing of folate and eventually serotonin. one of my is the made one, so I got switched to SNRIs and taking a supplement. This has made my drugs so much more effective. Finding other genes like this that can easily predict what medications will and will not work is amazing.

  35. @jhoan_replays7773 on

    "2:36" Nice video content!
    Have you ever come across – Lammywalness Erase Depression Guide ?
    Go to 𝗱𝗲𝗹𝗲𝘁𝗲𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 .𝗰𝗼𝗺 (remove spaces)
    It is a good one of a kind guide for beating depression fast minus the normal expense. Ive heard some great things about it and my brother in law got cool results with it.

  36. @blackmarbleboss9051 on

    "0:20" Cheers for the video content!
    Have you researched – Elumpa Depression Cure Alchemist ?
    Go to 𝗱𝗲𝗹𝗲𝘁𝗲𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 .𝗰𝗼𝗺 (remove spaces)
    It is a smashing one off product for discovering how to get rid of depression minus the normal expense. Ive heard some amazing things about it and my BF finally got astronomical success with it.

  37. @blackmarbleboss9051 on

    "0:25" Cheers for this,
    been searching for "best way to combat depression" for a while now, and I think this has helped. Have you heard about – Tarbally Destroy Depression Tactics ?
    Go to 𝗱𝗲𝗹𝗲𝘁𝗲𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 .𝗰𝗼𝗺 (remove spaces)
    It is a great exclusive guide for beating depression minus the hard work. Ive heard some great things about it and my m8 after many years got excellent results with it.

  38. @annalisette5897 on

    Another area of medicine that needs to be cleaned up is the default setting doctors in clinical practice seem to have. If their patients' ills do not respond 'normally', the patient is labelled mental and dumped on psychiatrists or mental health clinics.

    For example, COVID is FINALLY FORCING doctors and researchers to admit some viruses create long term disability and illness. Where I am from, if a patient is not significantly recovered in 21 days max, they are labelled mental as is, "don't you want to get well"?!?!?

    On the personal level, I was misdiagnosed with "mental illness", "panic disorder" for 37 years while doctors IGNORED a peculiar and ultimately dangerous heart rate. Finally it nearly killed me in 2012 and I got instant relief and a new life from a beta blocker!

    Not only do doctors and researchers need genetics and biomarkers for physical conditions in the brain and nervous system, but they must always delve for the PHYSIOLOGICAL CAUSES of so-called "mental" disorders. Telling a patient to think or talk him/herself well is exceedingly cruel and shows less expertise than was known during the official "Dark Ages"!

  43. @user-up5cy1it5m on

    "Planet Ayurveda’s holistic approach to treating depression with herbs and natural ingredients has really made a difference for me. I feel more grounded and balanced."

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