Rethinking mental health and antidepressant prescribing
In this episode, Dr Louise Newson is joined by Dr Mark Horowitz, who is a psychiatrist, researcher and world-leading expert in psychiatric medication withdrawal and deprescribing. Mark is also the lead author of the Maudsley Deprescribing Guidelines and co-founder of Outro Health, the only virtual clinic in the United States offering a clinically validated antidepressant tapering service.
Together, they explore how antidepressants, gabapentinoids and other psychoactive medications became so widely prescribed, and why stopping them is often far more difficult than starting them. The discussion looks closely at what the evidence actually shows about effectiveness, long-term risks, withdrawal effects and suicidality, particularly for women and younger people.
The conversation also examines how hormonal changes, life stressors and social factors are frequently overlooked, leading to the medicalisation of distress that may be a normal response to difficult circumstances.
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27 Comments
Thank you Drs for this great podcast. In 2009 I actually asked for drugs, twice of the Doctors.
I didn't know my worsening depression and anxiety were perimenopause. I had to taper off them slowly.
I wish there were more of Dr Mark Horowitz about, as I don't think most doctors know about de-prescribing.
Also, my perimenopause and menopause made changed my perception of my life circumstances, and I had an un-necessarily negative perspective on them. I was only able to see this in hindsight, once I got on enough oestrogen and testosterone. I can't thank you enough Dr Louise for these podcasts and your educational work, they made me feel heard for the first time in 15 years.
Thanks so much for a very important conversation. Antidepressants are routinely prescribed for people who are having typical normal responses to life's circumstances which could be helped more with counselling/psychotherapy,not ssris/antipsychotics
I have been on every SSRI SNRI and two different antipsychotics,,all of which made me feel so much worse (turns out I have ADHD and needed a stimulant which has been a game changer) but I'm also perimenopausal and I see how antidepressants are routinely prescribed to a lot of women for this also,, WRONG!!
I'm seeing a very good psychotherapist who is helping me navigate tough life circumstances and difficult situations, and for me personally this beats any drug I've put into my brain to alter chemicals that don't need to be altered especially when they made me feel so much worse,of course they have their place and absolutely help so many people and please take them if you feel you need to,they lift so many people, but work better alongside therapy,, combine the two and it helps even more…
Bless you Luise ♥️💎💐
I would suggest that antihistamines, antidepressants, GLP-1 related medication and some others have one thing in common. They all decrease the possibilities to perceive the longing or the need for change. To physically or emotionally feel an itch, discomfort (like sadness) or hunger for something and the rest of your physiology is quite balanced, is often the first sign of our old ways no longer being functional. A sign that we need to get rid of something bad, find something new or simply move forward no matter what the futur holds. I realised that when I had taken antihistamines for some time, that I probably also closed off for essential and healthy 'itches'. Although I didn't look into it there actually are connections, I decided to be very restrictive with antihistamines. Antidepressants and GLP-1 related medications for sure decrease the healthy longings and hungers, not only the unhealthy ones.
Very interesting. Thank you both.
Sorry for a long text. But this is important:
Mindfulness seems indeed to be helpful for many. But like anything that has the potency to help it most likely also has the potency to cause harm. Mindfulness like the body work I practice, The Rosen Method, which is also relying on the body's natural capability to readjust into a more relaxed and balanced state. Both mindfulness and the Rosen Method is gently poking a physical and mental habitual holding as a slight reminder that there might be things to let go of in order to relax etc. This poking is for most good in the way that the the body can check in with itself and decide whether to let go or hold on. But people who's body at the moment can't make that decision, are at risk to lose the protection the body is providing. Not being able to keep things on a distance, holding themselves upright or together can be very harmful. People with chemical addictions, being in a current crisis or having a mental health issue can all block people from being able to balance functionally balance themselves.
In my view also the setting where and the mind set in which mindfulness is taught is important.
I was happy to hear this brought up in Rusell Barkley's YT video 'Does Mindfulness Meditation Work for ADHD'. (At 14:50 Discussion of the potential side effects (adverse events) from mindfulness practices for ADHD.)
A channel that I very much recommend listening to from the first to the last video.
These same drugs are used for chronic pain patients, and there is a need for pain medicines. I just wish there was more information given drs on the dangers with high doses and addiction.
Very important topic. Thank you!
I had a female GP insist I should take antidepressants, she was extremely pushy stating I'd used them before. I informed her if I knew then what I know now I would not have touched them!! She then told me I just had to get on with it!!
It's good that this information is being put out there. Just hope people can get other support
Louise can you do something on acid reflux. Not ACV. But help with diet and coming off PPIs. I have had acid reflux and it got worse during menopause.
Mark Horowitz is doing such a good job of educating the public. I worked in mental health for almost a decade and was shocked at the lack of informed consent for psych meds.
Important and timely discussion. Thoughtful conversations around deprescribing and informed consent help patients make safer, more empowered decisions about their wellbeing.
Great podcast. Quite challenging for someone who worked as a psychiatric nurse for nearly 40 years. However, there is a huge problem in terms of access to psychological therapies and often medication is the only option available to us in that moment (I was not a prescriber). Sadly due to the general decimation of healthcare services, and even more so in mental health, we lack staff and resources and often rely on charities to provide the therapeutic activities we used to be able to provide in psychiatry. Of course, this is not a reason to go down the medical model route necessarily. But it also has to be remembered that only the most unwell people will be in psychiatric services who will need a lot of support to instigate alternative approaches.
And in terms of menopause and perimenopause, it is astounding that women can walk out of an 8 minute appointment with a prescription for SSRI's when natural hormones were not even considered. I really don't understand the fear and scaremongering around natural hormones, especially when comparing them to some medications.
Maybe GPs shouldn't be prescribing these drugs as they have no expertise nor time to figure it out?
I expected more of this conversation. It is very narrow. I agree that antidepressants should be assessed more carefully for younger people or for short term disstress and those who haven't tried lifestyle changes and therapy. I also agree patients should be informed about side effects and how to get off these drugs. What about patients who have tried lifestyle changes, therapy and don't get better? What shall those who suffer from stressors outside of their control like chronic illness, bullying and financial struggles? I expected qualified experienced doctors to discuss the full picture and not just one side. What about combined therapy and holistic approach where patients take meds short-term and figure out their issues in the meantime to feel better long-term?
Bien joué !
I wasnt suicidal until i was put on antidepressants
In only 2 months these drugs unleashed a hell on my brain and body. The doctors CT me from them because they are ignorant in deprescribing and recognizing adverse effects. For some of us they are toxic immediately. 2 1/2 years later still healing.🤍
Im 5 years post menopause and currently not on HRT. I have agoraphbia and autophobia since I began perimenopause 9 years ago. I tried several different HRT formulas of Estrogen and Progesterone but they often made me feel worse and I did not have support from any medical proffessional to navigate which doses or method to apply, to reach optimal balance. I was mostly told 'it was all in my head'. Im now under a psychatrist and have a support worker. Im currently on Quetiapine 25mg for the last 3 months and I feel terrible. I have put on 17lbs in weight which I have found very upsetting. Im now trying 'very slowly' to taper off. I since discovered that Quetiapine lowers Estrogen and Testosterone. I long thought the post natel depression id experienced and short stint of agoraphobia thereafter, was caused by unbalanced hormones and particularly low testosrerone which also occurs after giving birth. Low Testosterone also causes digestive issues and this probably explains why the Quetiapine has been been extremely problematic in making my acid reflux worse. Im a little lost on what to do now.
Always remember a prescription is a menu not a mandate. Whilst it can be a struggle to get appropriate medical treatment for menopause and other conditions, you always have agency over whether or not you take medication that is unsuitable or a poor fit. Yes doctors do overprescribe SSRIs and other psychiatric drugs, but if you walk that prescription to the chemist, collect it and swallow it, that's your decision alone.
I remember when you had to reside in the Asylum to get these pills. Now that they built all the big new drug stores everywhere people in the OR. ER, and HR are on them.
You don't even have to be a mental case yet to get them.
In some classrooms the teachers are and the students are on the same darn lucrative pills.
Psychiatwists and psychiatricks.
The basic reality of Pharmaceutical commerce.
SSRI destroyed my life long term. And coming off.
Very informative discussion and Dr Mark Horowitz scientific research and evidence is invaluable, as it dispels the commonly held view that there’s something wrong with the patients brain i.e chemical unbalance! So pleased to hear you explain that the symptoms are normal human responses to life tragedies, the problem is not in our brains but in the flawed, poorly resourced and I sufficiently trained mental health systems.
I prefer my antidepressants to HRT!!! They make me feel normal, HRT made me feel awful !! stop demonising antidepressants that save lives