Can Creatine Reduce Depression?
Is creatine just for growing muscles… or is there more to it?
You’ve heard creatine helps build strength and size—but what if it could also support your mental health? In this episode, we explore a powerful new study showing that creatine, when combined with cognitive-behavioural therapy (CBT), can significantly reduce symptoms of depression.
Doctors break down how this common supplement, often found in gym bags, might also belong in mental health conversations. It’s safe, accessible, and showing serious potential as a brain-boosting ally.
If you’re using creatine—or even just curious about how supplements affect your mood and mind—this is a conversation you need to hear.
#Creatine #MentalHealthSupport #CreatineForDepression #CBT #DoctorExplains #SupplementsForMood #BrainHealth #DepressionRecovery #TalkingWithDocs
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📄 Reference:
Sherpa NN, De Giorgi R, Ostinelli EG, et al. Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural therapy in depression: An 8-week pilot, double-blind, randomized, placebo-controlled trial in an under-resourced area. European Neuropsychopharmacology. 2025;90:28–35. https://doi.org/10.1016/j.euroneuro.2024.10.004
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#depression #mentalhealth #creatine #cbt #therapy #creatinebenefits #naturalmentalhealth #mentalwellness #wellnesssupport #depressionsupport #mentalhealthmatters #healthtalk #doctoradvice #healthtips
45 Comments
Was serotonin controlled for or did it not enter the picture in this pilot? Depression is such a complex condition.
I’ve battled depression since I was a teenager. I take creatine daily, and hope it helps.
😊😊👍👍🙏🙏
This is great! So glad I’m taking it
Doesn't creatine make you gain weight?
The fact that we get free videos on YouTube by Talking With Docs is truly a gift. 👍👍🥰
I was wondering if creatine was doing anything for me this last week and even put the bag in my Amazon shopping cart this morning. So I'll go ahead with my second bag as there seems to be little if any harm in taking about 5 grams a morning and it does get me to take a glass of water first thing. I still can't see my six-pack but there is still hope.
Creatine definitely lifts my mood!
Depression affects the English, French have joie de vivre thus will never be conquered! What? It's not like I wrote "Taking hormones to lessen heat flashes causes dementia (lady doc said so on Ted Talks),,,,
Any truth that creatine use can cause hair loss?
ooo… this is interesting, thank you. I think I need to watch your other creatine video now, could be worth a go.
The thumbnail is hilarious
Did they say how much was used in the study?
I'm all for taking creatine, there really so many producers of this I have no idea who and which is legit and which is basically sodium bicarbonate.
There are enough Psycho Doctors on social media, I'm very thankful Dr Z isn't one of them! 🤣
5 grams or 5 milligrams, you state both amounts?
i think I'll give it a try. I have concerns with finding a good source however Supplements aren't regulated here in the states & I don' want to either do myself harm or waste my money Any thoughts?
I’ve recently read that creatine is also beneficial for women in perimenopause years too! This additional possible benefit makes me want to go ahead and give it a shot, see if it helps. I’m also trying to build more muscle and exercise more so this is exciting, thank you guys for being another resource to make this decision 😊
what are the side effects of creatine? What individuals need to exercise caution when taking this ?There are many creatine rich foods; this should have been highlighted.
Good video. Could you do one about Lyme disease?
Is this available only in powder form?
Thanks for alerting me to this small study on Creatine.
I will turn 80 this year, I’m in good health. I have been taking Creatine now for 5 months, 2 x 5 mm in tea twice a day, (10mm) reason I take it to keep fit rowing my dingy about 3 times a week? And also, I had read that large amounts say 20mm a day will keep you brain function healthy? I don't take that a high dose? I do suffer from occasion depression which I find debilitating on the day if it is bothersome. I take one tablet 2700mm of St. John’s Wort only once on the day. I find in about 4 to 6 hrs my depression is resolved. I don't get the impression Creatine will work or prevent depression? Or maybe it does possibly a mild form of negative mood swing hard to know? However, when I do suffer debilitating depression (meaning I became weak minded, inactive as a result). taking one table only of St. John’s Wort does change my mood back to normal.
I've just started creatine hoping to get some benefit for my ADHD. Need more time and wish I had way to measure change.
For convenience I add my creatine to my daily protein shake which also contains a lot of fiber (ground flax, psyllium). Does the fiber negatively impact the absorption of creatine?
Thank you.
I always watch your video's to get rid off my depression !
If 5mg sounds like a good idea. Does that mean 10mg or 15mg will make me super happy?
I think there are a couple of meta studies that look at cognition and creatine. Compelling.
I started questioning everything after reading The Secret Health Reset, it made me realize how blinded we are by the health institutions, but it’s never too late. Life changing.
Why does the medical community push pharmaceuticals over natural remedies?
Creatine helped reduce my depression, but it was actually the book Breakout Dark Depression that truly cured it for good. Highly recommend it! 👍
Brilliant thumbnail! Love it, so creative and hilarious 😊 I have been taken creatine for years and it helps so much thru workouts and recovery, excellent add-in for mental health. Keep up the great content!
Before and after PRICELESS…
Is it of any benefit for seniors……
I’ve tried creating twice, but every time my HRV drops and my RHR increases. Don’t know what to do? Should I continue because of the benefits or is this a sign that my body doesn’t like creatine?
(There’s several threads on Reddit discussing this also, so it’s not just me, but if someone with actual education could say something?)
Hi, thank you for the video. What type of Creatine would you preferr? Becaues Monhydrate have I tried with a lot of water during the day (3g daily) but every day I felt that my throut dried during my sleep so much that I suddenly woke up grasping for air every day I took it. It was terreble feeling since even in the dream I noticed that I can not breath. Any suggestion here, why type could be better than Monohydrate and can it really be the cause the Creatine take? Since than one month is gone and hat no such terrible night at all. Any suggestion on which type of Creatine is better ? (Was drinking 1l more water than usually when I used it)
Just started questioning the benefits of creating as many people seem to be recommending it for bone health- thank you for sharing! And will now watch your other videos on creatine!
A little lazy to show in the video, protein powder (at least 100 grams) being dumped into a shaker.
Thank you Dear Doctors.
The Mind Made of Storms didn’t just teach me how to cope with my feelings—it taught me how to use them to shape my life. I used to let my emotions dictate my actions, but now, I’m using that energy to push me forward. The mental shift is crazy!
Getting free advice from License doctors is great. I hope your channel grows by the day.
Your sound quality has gotten really bad – have you started using new microphones or something?
❤
Get rid of my depression? Get rid of Trump.
Might try this. Perhaps. Thanks for the information.
What about creatine in food sources? At that level wouldn't it be another pointer towards a better diet first? I note you said that the study was in India, where in some areas diet can be restrictive. Would be interesting to hear your thoughts in a follow up if possible. Many thanks for your videos and the effort you put in.