GLP1 Drugs May Pose Mental Health Risks, New Study Warns
#glp1 #currentneuropharmacology #weightloss #diabetesmanagement
A new study published in Current Neuropharmacology has raised alarms about the potential mental health risks associated with Glucagon-like Peptide-1 (GLP1) receptor agonists—popular medications used in weight loss and diabetes management, including drugs like Ozempic. The international team of 24 researchers used advanced pharmacogenomic computational analysis to uncover links between GLP1 agonists and genes associated with mood regulation, depression, and suicidal ideation (SI).
The study highlights that while GLP1 agonists may benefit individuals with hyperdopaminergia (excess dopamine activity), they could be harmful to those with hypodopaminergia (low dopamine function). Genes such as DRD3, BDNF, and CREB1, which play key roles in mood and reward pathways, were found to be affected by these drugs. Chronic use, researchers say, may disrupt dopamine signaling and increase the risk of depression and suicidal thoughts.
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