Clarke, H. F., Dalley, J. W., Crofts, H. S., Robbins, T. W. & Roberts, A. C. Cognitive inflexibility after prefrontal serotonin depletion. Science 304, 878–880 (2004).

Article 
PubMed 

Google Scholar
 

Clarke, H. F., Walker, S., Dalley, J., Robbins, T. & Roberts, A. Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific. Cereb. Cortex 17, 18–27 (2007).

Article 
PubMed 

Google Scholar
 

Nilsson, S. R. O., Phillips, B. U., Axelsson, S. F. A. & Alsiö, J. in The Serotonin System (eds Tricklebank, M. D. & Daly, E.) 133–154 (Elsevier, 2019).

Maia, T. V. Reinforcement learning, conditioning, and the brain: successes and challenges. Cogn. Affect. Behav. Neurosci. 9, 343–364 (2009).

Article 
PubMed 

Google Scholar
 

Yin, H. H. & Knowlton, B. J. The role of the basal ganglia in habit formation. Nat. Rev. Neurosci. 7, 464–476 (2006).

Article 
PubMed 

Google Scholar
 

Collins, A. G. E. & Frank, M. J. Opponent actor learning (OpAL): modeling interactive effects of striatal dopamine on reinforcement learning and choice incentive. Psychol. Rev. 121, 337–366 (2014).

Article 
PubMed 

Google Scholar
 

Sutton, R. S. & Barto, A. G. Reinforcement Learning: An Introduction (MIT Press, 1998).

Behrens, T. E. J., Woolrich, M. W., Walton, M. E. & Rushworth, M. F. S. Learning the value of information in an uncertain world. Nat. Neurosci. 10, 1214–1221 (2007).

Article 
PubMed 

Google Scholar
 

Grossman, C. D., Bari, B. A. & Cohen, J. Y. Serotonin neurons modulate learning rate through uncertainty. Curr. Biol. 32, 586–599.e7 (2022).

Article 
PubMed 

Google Scholar
 

Gershman, S. J., Blei, D. M. & Niv, Y. Context, learning, and extinction. Psychol. Rev. 117, 197–209 (2010).

Article 
PubMed 

Google Scholar
 

Niv, Y. Learning task-state representations. Nat. Neurosci. 22, 1544–1553 (2019).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Redish, A. D., Jensen, S., Johnson, A. & Kurth-Nelson, Z. Reconciling reinforcement learning models with behavioral extinction and renewal: implications for addiction, relapse, and problem gambling. Psychol. Rev. 114, 784–805 (2007).

Article 
PubMed 

Google Scholar
 

Wilson, R. C., Takahashi, Y. K., Schoenbaum, G. & Niv, Y. Orbitofrontal cortex as a cognitive map of task space. Neuron 81, 267–279 (2014).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Hornak, J. et al. Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J. Cogn. Neurosci. 16, 463–478 (2004).

Article 
PubMed 

Google Scholar
 

Izquierdo, A., Brigman, J. L., Radke, A. K., Rudebeck, P. H. & Holmes, A. The neural basis of reversal learning: an updated perspective. Neuroscience 345, 12–26 (2017).

Article 
PubMed 

Google Scholar
 

Remijnse, P. L. et al. Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Arch. Gen. Psychiatry 63, 1225–1236 (2006).

Article 
PubMed 

Google Scholar
 

Tezcan, D., Tumkaya, S. & Bora, E. Reversal learning in patients with obsessive-compulsive disorder (OCD) and their unaffected relatives: is orbitofrontal dysfunction an endophenotype of OCD? Psychiatry Res. 252, 231–233 (2017).

Article 
PubMed 

Google Scholar
 

Fellows, L. K. The role of orbitofrontal cortex in decision making. Ann. N. Y. Acad. Sci. 1121, 421–430 (2007).

Article 
PubMed 

Google Scholar
 

Maia, T. V. & McClelland, J. L. The somatic marker hypothesis: still many questions but no answers. Trends Cogn. Sci. 9, 162–164 (2005).

Article 

Google Scholar
 

Rudebeck, P. H., Saunders, R. C., Prescott, A. T., Chau, L. S. & Murray, E. A. Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating. Nat. Neurosci. 16, 1140–1145 (2013).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Bradfield, L. A., Dezfouli, A., van Holstein, M., Chieng, B. & Balleine, B. W. Medial orbitofrontal cortex mediates outcome retrieval in partially observable task situations. Neuron 88, 1268–1280 (2015).

Article 
PubMed 

Google Scholar
 

Schuck, N. W., Cai, M. B., Wilson, R. C. & Niv, Y. Human orbitofrontal cortex represents a cognitive map of state space. Neuron 91, 1402–1412 (2016).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Schuck, N. W., Wilson, R. & Niv, Y. in Goal-Directed Decision Making: Computations and Neural Circuits (eds Morris, R. et al.) 259–278 (Academic Press, 2018).

Stalnaker, T. A., Cooch, N. K. & Schoenbaum, G. What the orbitofrontal cortex does not do. Nat. Neurosci. 18, 620–627 (2015).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Wikenheiser, A. M. & Schoenbaum, G. Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex. Nat. Rev. Neurosci. 17, 513–523 (2016).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Clarke, H. F. et al. Prefrontal serotonin depletion affects reversal learning but not attentional set shifting. J. Neurosci. 25, 532–538 (2005).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Kanen, J. W. et al. Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans. Mol. Psychiatry 26, 7200–7210 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Matias, S., Lottem, E., Dugué, G. P. & Mainen, Z. F. Activity patterns of serotonin neurons underlying cognitive flexibility. eLife 6, e20552 (2017).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Roberts, C., Sahakian, B. J. & Robbins, T. W. Psychological mechanisms and functions of 5-HT and SSRIs in potential therapeutic change: lessons from the serotonergic modulation of action selection, learning, affect, and social cognition. Neurosci. Biobehav. Rev. 119, 138–167 (2020).

Article 
PubMed 

Google Scholar
 

Zhukovsky, P. et al. Perseveration in a spatial-discrimination serial reversal learning task is differentially affected by MAO-A and MAO-B inhibition and associated with reduced anxiety and peripheral serotonin levels. Psychopharmacology 234, 1557–1571 (2017).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Barlow, R. L. et al. Markers of serotonergic function in the orbitofrontal cortex and dorsal raphé nucleus predict individual variation in spatial-discrimination serial reversal learning. Neuropsychopharmacology 40, 1619–1630 (2015).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Groman, S. M. et al. Monoamine levels within the orbitofrontal cortex and putamen interact to predict reversal learning performance. Biol. Psychiatry 73, 756–762 (2013).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Maia, T. V. & Cano-Colino, M. The role of serotonin in orbitofrontal function and obsessive-compulsive disorder. Clin. Psychol. Sci. 3, 460–482 (2015).

Article 

Google Scholar
 

Roberts, A. C. The importance of serotonin for orbitofrontal function. Biol. Psychiatry 69, 1185–1191 (2011).

Article 
PubMed 

Google Scholar
 

Alsiö, J. et al. Serotonergic innervations of the orbitofrontal and medial-prefrontal cortices are differentially involved in visual discrimination and reversal learning in rats. Cereb. Cortex 31, 1090–1105 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Masaki, D. et al. Relationship between limbic and cortical 5-HT neurotransmission and acquisition and reversal learning in a go/no-go task in rats. Psychopharmacology 189, 249–258 (2006).

Article 
PubMed 

Google Scholar
 

Chan, S. C. Y., Niv, Y. & Norman, K. A. A probability distribution over latent causes, in the orbitofrontal cortex. J. Neurosci. 36, 7817–7828 (2016).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Huys, Q. J. M. & Petzschner, F. H. Failure modes of the will: from goals to habits to compulsions? Am. J. Psychiatry 172, 216–218 (2015).

Article 
PubMed 

Google Scholar
 

Rigoux, L., Stephan, K. E. & Petzschner, F. H. Beliefs, compulsive behavior and reduced confidence in control. PLoS Comput. Biol. 20, e1012207 (2024).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Maia, T. V., Cooney, R. E. & Peterson, B. S. The neural bases of obsessive–compulsive disorder in children and adults. Dev. Psychopathol. 20, 1251 (2008).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Menzies, L. et al. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci. Biobehav. Rev. 32, 525–549 (2008).

Article 
PubMed 

Google Scholar
 

Piras, F. et al. Widespread structural brain changes in OCD: a systematic review of voxel-based morphometry studies. Cortex 62, 89–108 (2015).

Article 
PubMed 

Google Scholar
 

Rotge, J.-Y. et al. Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J. Psychiatry Neurosci. 33, 405–412 (2008).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Rotge, J.-Y. et al. Meta-analysis of brain volume changes in obsessive-compulsive disorder. Biol. Psychiatry 65, 75–83 (2009).

Article 
PubMed 

Google Scholar
 

Thorsen, A. L. et al. Emotional processing in obsessive-compulsive disorder: a systematic review and meta-analysis of 25 functional neuroimaging studies. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 3, 563–571 (2018).

PubMed 
PubMed Central 

Google Scholar
 

Whiteside, S. P., Port, J. D. & Abramowitz, J. S. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res. 132, 69–79 (2004).

Article 
PubMed 

Google Scholar
 

Maia, T. V. & McClelland, J. L. A neurocomputational approach to obsessive-compulsive disorder. Trends Cogn. Sci. 16, 14–15 (2012).

Article 
PubMed 

Google Scholar
 

Rolls, E. T., Loh, M. & Deco, G. An attractor hypothesis of obsessive–compulsive disorder. Eur. J. Neurosci. 28, 782–793 (2008).

Article 
PubMed 

Google Scholar
 

Chamberlain, S. R. et al. Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 321, 421–422 (2008).

Article 
PubMed 

Google Scholar
 

Freyer, T. et al. Frontostriatal activation in patients with obsessive-compulsive disorder before and after cognitive behavioral therapy. Psychol. Med. 41, 207–216 (2011).

Article 
PubMed 

Google Scholar
 

Remijnse, P. L. et al. Differential frontal-striatal and paralimbic activity during reversal learning in major depressive disorder and obsessive-compulsive disorder. Psychol. Med. 39, 1503–1518 (2009).

Article 
PubMed 

Google Scholar
 

Apergis-Schoute, A. M. et al. Perseveration and shifting in obsessive-compulsive disorder as a function of uncertainty, punishment, and serotonergic medication. Biol. Psychiatry Glob. Open Sci. 4, 326–335 (2024).

Article 
PubMed 

Google Scholar
 

Hirschtritt, M. E., Bloch, M. H. & Mathews, C. A. Obsessive-compulsive disorder: advances in diagnosis and treatment. JAMA 317, 1358–1367 (2017).

Article 
PubMed 

Google Scholar
 

Sanchez, C., Reines, E. H. & Montgomery, S. A. A comparative review of escitalopram, paroxetine, and sertraline: are they all alike? Int. Clin. Psychopharmacol. 29, 185–196 (2014).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Saxena, S. & Rauch, S. L. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr. Clin. North Am. 23, 563–586 (2000).

Article 
PubMed 

Google Scholar
 

Foa, E. B. et al. The Obsessive-Compulsive Inventory: development and validation of a short version. Psychol. Assess. 14, 485–496 (2002).

Article 
PubMed 

Google Scholar
 

Clark, D. A. et al. A question of perspective: the association between intrusive thoughts and obsessionality in 11 countries. J. Obsessive Compuls. Relat. Disord. 3, 292–299 (2014).

Article 

Google Scholar
 

Fullana, M. A. et al. Obsessions and compulsions in the community: prevalence, interference, help-seeking, developmental stability, and co-occurring psychiatric conditions. Am. J. Psychiatry 166, 329–336 (2009).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Abramowitz, J. S. et al. The relevance of analogue studies for understanding obsessions and compulsions. Clin. Psychol. Rev. 34, 206–217 (2014).

Article 
PubMed 

Google Scholar
 

Draper, C. F. et al. Menstrual cycle rhythmicity: metabolic patterns in healthy women. Sci. Rep. 8, 1–15 (2018).

Article 

Google Scholar
 

Jovanovic, H. et al. A PET study of 5-HT1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria. Psychiatry Res. 148, 185–193 (2006).

Article 
PubMed 

Google Scholar
 

Frank, M. J., Moustafa, A. A., Haughey, H. M., Curran, T. & Hutchison, K. E. Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proc. Natl Acad. Sci. USA 104, 16311–16316 (2007).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Guitart-Masip, M. et al. Go and no-go learning in reward and punishment: interactions between affect and effect. NeuroImage 62, 154–166 (2012).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Conceição, V. A. & Maia, T. V. in Computational Psychiatry: A Primer (ed. Seriès, P.) 205–246 (MIT Press, 2020).

Collins, A. G. E. & Frank, M. J. Cognitive control over learning: creating, clustering, and generalizing task-set structure. Psychol. Rev. 120, 190–229 (2013).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Collins, A. G. E. & Frank, M. J. Neural signature of hierarchically structured expectations predicts clustering and transfer of rule sets in reinforcement learning. Cognition 152, 160–169 (2016).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Babayan, B. M., Uchida, N. & Gershman, S. J. Belief state representation in the dopamine system. Nat. Commun. 9, 1891 (2018).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Gershman, S. J. & Uchida, N. Believing in dopamine. Nat. Rev. Neurosci. 20, 703–714 (2019).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Starkweather, C. K., Babayan, B. M., Uchida, N. & Gershman, S. J. Dopamine reward prediction errors reflect hidden-state inference across time. Nat. Neurosci. 20, 581–589 (2017).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Lartillot, N. & Philippe, H. Computing Bayes factors using thermodynamic integration. Syst. Biol. 55, 195–207 (2006).

Article 
PubMed 

Google Scholar
 

Sengupta, B., Friston, K. J. & Penny, W. D. Gradient-free MCMC methods for dynamic causal modelling. NeuroImage 112, 375–381 (2015).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Daunizeau, J., Adam, V. & Rigoux, L. VBA: a probabilistic treatment of nonlinear models for neurobiological and behavioural data. PLoS Comput. Biol. 10, e1003441 (2014).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Hampton, A. N., Bossaerts, P. & O’Doherty, J. P. The role of the ventromedial prefrontal cortex in abstract state-based inference during decision making in humans. J. Neurosci. 26, 8360–8367 (2006).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Schlagenhauf, F. et al. Striatal dysfunction during reversal learning in unmedicated schizophrenia patients. NeuroImage 89, 171–180 (2014).

Article 
PubMed 

Google Scholar
 

Kanen, J. W., Ersche, K. D., Fineberg, N. A., Robbins, T. W. & Cardinal, R. N. Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents. Psychopharmacology 236, 2337–2358 (2019).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Marzuki, A. A. et al. Association of environmental uncertainty with altered decision-making and learning mechanisms in youths with obsessive-compulsive disorder. JAMA Netw. Open 4, e2136195 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Rygula, R. et al. Role of central serotonin in anticipation of rewarding and punishing outcomes: effects of selective amygdala or orbitofrontal 5-HT depletion. Cereb. Cortex 25, 3064–3076 (2015).

Article 
PubMed 

Google Scholar
 

Luo, Q. et al. Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making. Neuropsychopharmacology 49, 600–608 (2024).

Article 
PubMed 

Google Scholar
 

Robbins, T. W. & Cardinal, R. N. Computational psychopharmacology: a translational and pragmatic approach. Psychopharmacology 236, 2295–2305 (2019).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Langley, C. et al. Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study. Neuropsychopharmacology 48, 664–670 (2023).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Gardier, A., Malagié, I., Trillat, A., Jacquot, C. & Artigas, F. Role of 5-HT1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: recent findings from in vivo microdialysis studies. Fundam. Clin. Pharmacol. 10, 16–27 (1996).

Article 
PubMed 

Google Scholar
 

Altman, D. G. & Bland, J. M. Statistics notes: absence of evidence is not evidence of absence. BMJ 311, 485 (1995).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Cohen, J. & Nee, J. C. M. Estimators for two measures of association for set correlation. Educ. Psychol. Meas. 44, 907–917 (1984).

Article 

Google Scholar
 

Guitart-Masip, M. et al. Differential, but not opponent, effects of l-DOPA and citalopram on action learning with reward and punishment. Psychopharmacology 231, 955–966 (2014).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Cools, R., Nakamura, K. & Daw, N. D. Serotonin and dopamine: unifying affective, activational, and decision functions. Neuropsychopharmacology 36, 98–113 (2011).

Article 
PubMed 

Google Scholar
 

Daw, N. D., Kakade, S. & Dayan, P. Opponent interactions between serotonin and dopamine. Neural Netw. 15, 603–616 (2002).

Article 
PubMed 

Google Scholar
 

Dayan, P. & Huys, Q. J. M. Serotonin in affective control. Annu. Rev. Neurosci. 32, 95–126 (2009).

Article 
PubMed 

Google Scholar
 

Bloch, M. H., McGuire, J., Landeros-Weisenberger, A., Leckman, J. F. & Pittenger, C. Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder. Mol. Psychiatry 15, 850–855 (2010).

Article 
PubMed 

Google Scholar
 

Pittenger, C. & Bloch, M. H. Pharmacological treatment of obsessive-compulsive disorder. Psychiatr. Clin. North Am. 37, 375–391 (2014).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Furr, A., Lapiz-Bluhm, M. D. & Morilak, D. A. 5-HT2A receptors in the orbitofrontal cortex facilitate reversal learning and contribute to the beneficial cognitive effects of chronic citalopram treatment in rats. Int. J. Neuropsychopharmacol. 15, 1295–1305 (2012).

Article 
PubMed 

Google Scholar
 

Walker, S. C., Robbins, T. W. & Roberts, A. C. Differential contributions of dopamine and serotonin to orbitofrontal cortex function in the marmoset. Cereb. Cortex 19, 889–898 (2009).

Article 
PubMed 

Google Scholar
 

Bari, A. et al. Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats. Neuropsychopharmacology 35, 1290–1301 (2010).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Blier, P., Pineyro, G., El Mansari, M., Bergeron, R. & Montigny, C. Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Ann. N. Y. Acad. Sci. 861, 204–216 (1998).

Article 
PubMed 

Google Scholar
 

Hjorth, S. Serotonin 5-HT1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study. J. Neurochem. 60, 776–779 (1993).

Article 
PubMed 

Google Scholar
 

Beyer, C. E. & Cremers, T. I. F. H. Do selective serotonin reuptake inhibitors acutely increase frontal cortex levels of serotonin? Eur. J. Pharmacol. 580, 350–354 (2008).

Article 
PubMed 

Google Scholar
 

Nord, M., Finnema, S. J., Halldin, C. & Farde, L. Effect of a single dose of escitalopram on serotonin concentration in the non-human and human primate brain. Int. J. Neuropsychopharmacol. 16, 1577–1586 (2013).

Article 
PubMed 

Google Scholar
 

Invernizzi, R., Belli, S. & Samanin, R. Citalopram’s ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug’s effect in the frontal cortex. Brain Res. 584, 322–324 (1992).

Article 
PubMed 

Google Scholar
 

Hirano, K. et al. Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. Br. J. Pharmacol. 144, 695–702 (2005).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Meyer, J. H. et al. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am. J. Psychiatry 161, 826–835 (2004).

Article 
PubMed 

Google Scholar
 

Chamberlain, S. R. et al. Neurochemical modulation of response inhibition and probabilistic learning in humans. Science 311, 861–863 (2006).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Skandali, N. et al. Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans. Neuropsychopharmacology 43, 2645 (2018).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Fritze, S., Spanagel, R. & Noori, H. R. Adaptive dynamics of the 5-HT systems following chronic administration of selective serotonin reuptake inhibitors: a meta-analysis. J. Neurochem. 142, 747–755 (2017).

Article 
PubMed 

Google Scholar
 

Cools, R., Roberts, A. C. & Robbins, T. W. Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn. Sci. 12, 31–40 (2008).

Article 
PubMed 

Google Scholar
 

Boureau, Y.-L. & Dayan, P. Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology 36, 74–97 (2011).

Article 
PubMed 

Google Scholar
 

Michely, J., Eldar, E., Erdman, A., Martin, I. M. & Dolan, R. J. Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers. Commun. Biol. 5, 812 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Loosen, A. M. & Hauser, T. U. Towards a computational psychiatry of juvenile obsessive-compulsive disorder. Neurosci. Biobehav. Rev. 118, 631–642 (2020).

Article 
PubMed 

Google Scholar
 

Fradkin, I., Adams, R. A., Parr, T., Roiser, J. P. & Huppert, J. D. Searching for an anchor in an unpredictable world: a computational model of obsessive compulsive disorder. Psychol. Rev. 127, 672–699 (2020).

Article 
PubMed 

Google Scholar
 

Fradkin, I., Ludwig, C., Eldar, E. & Huppert, J. D. Doubting what you already know: uncertainty regarding state transitions is associated with obsessive compulsive symptoms. PLoS Comput. Biol. 16, e1007634 (2020).

Article 
PubMed 
PubMed Central 

Google Scholar
 

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5 (American Psychiatric Association, 2013).

Foa, E. B. et al. DSM-IV field trial: obsessive-compulsive disorder. Am. J. Psychiatry 152, 90–96 (1995).

PubMed 

Google Scholar
 

Jakubovski, E. et al. Dimensional correlates of poor insight in obsessive-compulsive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 1677–1681 (2011).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Vaghi, M. M. et al. Compulsivity reveals a novel dissociation between action and confidence. Neuron 96, 348–354.e4 (2017).

Article 
PubMed 
PubMed Central 

Google Scholar
 

White, J., Tannenbaum, C., Klinge, I., Schiebinger, L. & Clayton, J. The integration of sex and gender considerations into biomedical research: lessons from international funding agencies. J. Clin. Endocrinol. Metab. 106, 3034–3048 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Hall, E. & Steiner, M. Serotonin and female psychopathology. Women’s Health 9, 85–97 (2013).

Article 
PubMed 

Google Scholar
 

Thorne, B. N., Ellenbroek, B. A. & Day, D. J. Sex bias in the serotonin transporter knockout model: implications for neuropsychiatric disorder research. Neurosci. Biobehav. Rev. 134, 104547 (2022).

Article 
PubMed 

Google Scholar
 

Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals (International Committee of Medical Journal Editors (ICMJE), 2025); https://www.icmje.org/icmje-recommendations.pdf

Gönner, S., Leonhart, R. & Ecker, W. The Obsessive–Compulsive Inventory-Revised (OCI-R): validation of the German version in a sample of patients with OCD, anxiety disorders, and depressive disorders. J. Anxiety Disord. 22, 734–749 (2008).

Article 
PubMed 

Google Scholar
 

Watkins, C. J. C. H. Learning from Delayed Rewards. PhD thesis, Univ. Cambridge (1989).

Maia, T. V. & Conceição, V. A. The roles of phasic and tonic dopamine in tic learning and expression. Biol. Psychiatry 82, 401–412 (2017).

Article 
PubMed 

Google Scholar
 

Clarke, H. F. et al. Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity. J. Neurosci. 34, 7663–7676 (2014).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Daw, N. D. in Decision Making, Affect, and Learning: Attention and Performance XXIII (eds Delgado, M. R., Phelps, E. A. & Robbins, T. W.) 3–38 (Oxford Univesity Press, 2011).

Robert, C. & Casella, G. Monte Carlo Statistical Methods (Springer, 2013).

Penny, W. D. Comparing dynamic causal models using AIC, BIC and free energy. NeuroImage 59, 319–330 (2012).

Article 
PubMed 

Google Scholar
 

Frässle, S. et al. TAPAS: an open-source software package for translational neuromodeling and computational psychiatry. Front. Psychiatry 12, 680811 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Aponte, E. A. et al. mpdcm: a toolbox for massively parallel dynamic causal modeling. J. Neurosci. Methods 257, 7–16 (2016).

Article 
PubMed 

Google Scholar
 

Aponte, E. A., Schöbi, D., Stephan, K. E. & Heinzle, J. The Stochastic Early Reaction, Inhibition, and late Action (SERIA) model for antisaccades. PLoS Comput. Biol. 13, e1005692 (2017).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Calderhead, B. & Girolami, M. Estimating Bayes factors via thermodynamic integration and population MCMC. Comput. Stat. Data Anal. 53, 4028–4045 (2009).

Article 

Google Scholar
 

Gelman, A., Carlin, J. B., Stern, H. S. & Rubin, D. B. Bayesian Data Analysis Vol. 2 (Chapman & Hall/CRC, 2014).

Rigoux, L., Stephan, K. E., Friston, K. J. & Daunizeau, J. Bayesian model selection for group studies—revisited. NeuroImage 84, 971–985 (2014).

Article 
PubMed 

Google Scholar
 

Stephan, K. E., Penny, W. D., Daunizeau, J., Moran, R. J. & Friston, K. J. Bayesian model selection for group studies. NeuroImage 46, 1004–1017 (2009).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Winkler, A. M., Renaud, O., Smith, S. M. & Nichols, T. E. Permutation inference for canonical correlation analysis. NeuroImage 220, 117065 (2020).

Article 
PubMed 
PubMed Central 

Google Scholar
 

McGarigal, K., Stafford, S. & Cushman, S. Multivariate Statistics for Wildlife and Ecology Research (Springer, 2000).

Sherry, A. & Henson, R. K. Conducting and interpreting canonical correlation analysis in personality research: a user-friendly primer. J. Pers. Assess. 84, 37–48 (2005).

Article 
PubMed 

Google Scholar
 

RStudio Team. RStudio: integrated development environment for R. http://www.rstudio.com/ (2020).

R Core Team R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, 2021).

The jamovi project. jamovi (version 1.6.23) [Computer Software]. https://www.jamovi.org (2020).

Hohl, K. & Dolcos, S. Measuring cognitive flexibility: a brief review of neuropsychological, self-report, and neuroscientific approaches. Front. Hum. Neurosci. 18, 1331960 (2024).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich. Dataset from a probabilistic Go/NoGo reversal-learning task. Zenodo https://doi.org/10.5281/zenodo.10066829 (2024).

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